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disease, the author daily meeting with scabies cases treated for months for eczema, urticaria, prurigo of digestive origin, etc. Concluding, the author urges attention to the extreme frequency of the disease, careful examination for its signs in all cases of itching, and the institution of proper hygienic and prophylactic measures by the r.ulhoritics. Effect of Injections of Hemolytic Streptococci in Susceptible and Insusceptible Animals. — J. Gardner Hopkins and Julia T. Parker {Journal of Experimental Medicine, January, 1918) found that hemolytic streptococci of rather low virulence for rabbits, given in sublethal dose, may completely disappear from the blood stream within a few hours. If a lethal injection is used, over ninety per cent, of the cocci are removed from the circu- lation within the first few minutes and subsequent blood cultures are the lowest in two to three hours, but after four to six hours, the number of organ- isms again begins to increase. Even with lethal doses, cultures of one c. c. of blood may show no colonies after Is It Legal To Buy Viagra Online In Usa two or three hours, but usually strejjtococci do not completely disappear Is It Legal To Buy Viagra Online In Usa after sucli an injection. Hemolytic streptococci injected into the circulation of cats are C|uickly withdrawn and apjjear in the lung in the largest numbers, and in decreasing numbers in the Is It Legal To Buy Viagra Online In Usa liver, spleen, bone mar- row, lymph nodes, muscle, and kidney. The lung rids itself soonest of the streptococci, although a film of ground lung tissue may show them for sev- eral days. In the liver they are killed less rapidly, and the spleen may show viable organisms for some time. The authors believe the bactericidal power depends on Is It Legal To Buy Viagra Online In Usa the living condition of the cells, and it may be shown in a piece of excised lung, but not in lung extract. In experiments with rabbits, which are susceptible animals, about equal numbers are absorbed by the lung, liver, and spleen, and the muscles take up a considerable number. As in the cat, the streptococci taken up by the lung and liver are quickly killed, but they lodge in the muscles and multiply there, so that four to eight hours after injection, the number in the blood stream begins to increase. The resulting septicemia is probably due to the washing out of organisms from the in- fected tissues. The authors were unable to im- munize rabbits successfully, but in some of the treated animals the distribution of the organisms among various organs resembled that found in in- susceptible animals. Early Diagnosis of Tuberculosis by the Use of the X Rayed Guineapig. — W. H. Eckford {Jour- nal of Laboratory and Clinical Medicine, December. 1917) describes the following method as a routine for using x rayed guineapigs in the early diagnosis of tuberculosis: The material is Is It Legal To Buy Viagra Online In Usa prepared accord- ing to its nature, by digestion with four per cent, potassium hydroxide and centrifugalization and washing before injection, by digestion with fifteen per cent, antiformin, or by simple centrifugalization From 0.5 to one c. c. of the prepared material is injected into the groin and the abdomen of the ani- mal, which is then exposed every second day to a five minute dose of the x rays for at least three exposures. If a nodule develops which persists after two weeks, it is removed under a local anes- thetig for diagnosis. If positive, it can be reported at once. If negative, the animal should be kept at least six weeks to await developments, but at the end of that time, if the pig has been thoroughly rayed, the test may safely be called negative. Eck- ford recommends frequently repeated doses of x ray as having a more certain effect in increasing the susceptibility of the guineapigs than single doses. He states that the destruction of lymphoid cells in itself is insufficient to explain the decreased resistance. Intraspinal Injections of Epinephrine. — John Aucr and S. J. Mcltzer {Journal A. M. A.. Janu- ary 12, 1918) call attention to the occurrence of very low blood pressures in connection with the dangerous stages of a variety of diseases and in states of shock, and point out that any means of raising the general blood pressure increases the chances of recovery. Epinephrine has been em- ployed for this purpose by various channels of ad- ministration, but its action is fleeting when given intravenously and is followed by a marked fall of pressure. Intramuscular injection as well as sub- cutaneous, gives a more lasting rise of blood pres- sure, but a relatively small one. On the other hand, experiments on monkeys have shown that the in- traspinal injection of the drug is safe and leads to a pronounced and fairly prolonged elevation of the blood pressure. Its similar use in human beings would seem to offer a satisfactory method of raising blood pressure, for not less than an hour followMng the injection, after which the subcutane- ous injection of the drug might be used to main- tain the effects. The initial dose intraspinallv should not be less than three mils of the i : i.ooo solution. MISCELLANY FROM HOME AND FOREIGN JOURNALS. 379 Solvent Action of Antiseptics Is It Legal To Buy Viagra Online In Usa on Necrotic Tissue.— Herbert D. Taylor and J. Harold Austin (Journal of Expcritnental Medicine, January, 1918) conducted experiments to determine "the importance in the solvent action of antiseptics of three factors: the alkalinity, the nature of the chlorinated anti- septic employed, and the chlorine concentration of the latter. The antiseptics used were chloramine-T solutions, hypochlorite solutions, chlorinated oils, and dichloramine-T. They found that Dakin's hypochlorite solution is capable of dissolving necrotic tissue, pus, and plasma clot in the con- centration and reaction used clinically, but that chloramine-T and dichloramine-T do not possess that power. The authors disagree with Fiessinger and his coworkers in their view that the solvent action of the hypochlorite solutions is due to their alkalinity, as the experiments reported show thai the solvent action of Dakin's hypochlorite solution in the degree of alkalinity used clinically is due pri- marily to the hypochlorite content, though the slight alkalinity, while in itself without solvent action, increases the effectiveness of the hypochlorite. In